Xenopus tropicalis goes genetic
نویسندگان
چکیده
منابع مشابه
Genetic Screens for Mutations Affecting Development of Xenopus tropicalis
We present here the results of forward and reverse genetic screens for chemically-induced mutations in Xenopus tropicalis. In our forward genetic screen, we have uncovered 77 candidate phenotypes in diverse organogenesis and differentiation processes. Using a gynogenetic screen design, which minimizes time and husbandry space expenditures, we find that if a phenotype is detected in the gynogene...
متن کاملDecoding development in Xenopus tropicalis.
Xenopus tropicalis is rapidly being adopted as a model organism for developmental biology research and has enormous potential for increasing our understanding of how embryonic development is controlled. In recent years there has been a well-organized initiative within the Xenopus community, funded largely through the support of the National Institutes of Health in the US, to develop X. tropical...
متن کاملExpression of Xenopus tropicalis HNF6/Onecut-1.
Onecut genes belong to a family of transcription factors that are known to be important in embryonic development. In the present study, we analyzed the pattern of expression of Onecut-1/HNF6 in Xenopus tropicalis using RT-PCR and whole mount in situ hybridization. Expression of the Xenopus tropicalis Onecut-1/HNF6 gene was found to be conserved in the neural tube, the sensory placodes and in th...
متن کاملProposal for sequencing the Xenopus tropicalis genome
Preface to Xenopus White Paper. This paper is being submitted after the recent announcement that the Joint Genome Institute is planning an extensive effort to sequence the Xenopus tropicalis genome. As discussed below, the current plan from JGI is for 6X coverage of the genome using a shotgun sequencing strategy. This paper is being submitted because in addition to the JGI commitment, it would ...
متن کاملComparison of TALEN scaffolds in Xenopus tropicalis
Transcription activator-like effector nucleases (TALENs) are facile and potent tools used to modify a gene of interest for targeted gene knockout. TALENs consist of an N-terminal domain, a DNA-binding domain, and a C-terminal domain, which are derived from a transcription activator-like effector, and the non-specific nuclease domain of FokI. Using Xenopus tropicalis (X. tropicalis), we compared...
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ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2006
ISSN: 1471-0056,1471-0064
DOI: 10.1038/nrg1931